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Enhanced inhibition efficiency of compound F2736-3056 against 3G-resistant FOP-mutant (V447T). Impact of the inhibitors was assessed using a previously described cell-to-cell fusion assay [30]. HOP and either FOP or FOP-V447T glycoproteins were co-expressed in Vero-cSLAM cells that were individually treated with DMSO (no compound), 3G, F2261-0043 and F2736-3056. Pictures of representative fields of view illustrating the extent of cell-to-cell fusion are shown for each condition.
