Table 2.
Interactions between PPARG2 Pro12Ala allele polymorphism and alcohol, fish, and fried food consumption in observational studies in relation to cancer risk.
| OR/IRR (95% CI) | ||||||||
|---|---|---|---|---|---|---|---|---|
| PPARG2 Pro12Ala Allele Polymorphism | ||||||||
| First Author/Publication Year | Age | Women (%) | Study Location |
Cancer Site | Stratified Categories | CC | CG + GG | p-Value for Interaction |
| Petersen 2012 [27] | 57/57 | 100% | Denmark | Breast cancer | Alcohol intake | |||
| Per 10 g alcohol/day | 1.13 (1.04–1.23) | 0.95 (0.83–1.08) | 0.02 | |||||
| Vogel 2007 [29] | 59/56 | 44% | Denmark | Colorectal cancer | Alcohol intake | |||
| Per 10 g alcohol/day | 1.03 (0.96–1.10) | 1.22 (1.07–1.39) | 0.02 | |||||
| Jiang 2005 [25] | 20–75 | 36% | India | Colorectal cancer | Fish intake | |||
| Low | Reference | 1.14 (0.72–1.81) | 0.36 | |||||
| High | 0.74 (0.46–1.18) | 0.51 (0.20–1.27) | ||||||
| Kuriki 2006 [30] (study 2) | 58.9 | 37% | Japan | Colorectal cancer | Fish | |||
| Low | Reference | 0.69 (0.23–2.10) | 0.49 | |||||
| Middle | 0.93 (0.66–1.29) | 1.09 (0.34–3.47) | ||||||
| High | 0.91 (0.61–1.34) | 0.34 (0.04–2.81) | ||||||
| Fried foods | ||||||||
| Low | Reference | 0.23 (0.03–1.82) | 0.01 | |||||
| Middle | 0.94 (0.65–1.34) | 0.20 (0.03–1.56) | ||||||
| High | 0.77 (0.51–1.16) | 2.04 (0.74–5.63) | ||||||
| Deep-fried foods | ||||||||
| Low | Reference | 0.45 (0.10–2.05) | 0.17 | |||||
| Middle | 0.81 (0.59–1.13) | 0.59 (0.19–1.77) | ||||||
| High | 0.68 (0.44–1.03) | 1.33 (0.32–5.49) | ||||||