Table 3.

Interactions between PPARG2 Pro12Ala allele polymorphism and antioxidant intake in observational studies in relation to cancer risk.

					OR (95% CI)
					PPARG2 Pro12Ala Allele Polymorphism
First Author/Publication Year	Age (Range)	Women (%)	Study Location	Stratified Categories	CC	CG + GG	CC	CG + GG
Landi 2003 [26]	<58–>75	43%	Spain		Colorectal Cancer
				Vitamin A intake
				Low	Reference	0.25 (0.12–0.53)
				High	Reference	1.08 (0.53–2.20) *
Murtaugh 2005 [23]	30–79	45% (colon)	USA		Colon Cancer		Rectal Cancer
		42% (rectum)		Beta-Carotene
				High	Reference	0.71 (0.52–0.96)	Reference	1.08 (0.73–1.61)
				Middle	0.94 (0.77–1.16)	0.85 (0.65–1.13)	1.03 (0.77–1.37)	0.43 (0.94–2.18)
				Low	0.82 (0.65–1.02)	0.82 (0.61–1.10)	1.15 (0.83–1.58)	1.28 (0.83–1.97)
				Lutein
				High	Reference	0.63 (0.44–0.89)	Reference	1.06 (0.72–1.57)
				Middle	0.89 (0.72–1.10)	0.82 (0.61–1.10)	0.95 (0.72–1.27)	1.19 (0.79–1.79)
				Low	0.90 (0.71–1.13)	0.90 (0.71–1.13) *	0.90 (0.64–1.25)	1.15 (0.73–1.79)
				Lycopene
				High	Reference	0.75 (0.52–1.06)	Reference	0.89 (0.61–1.30)
				Middle	1.02 (0.82–1.27)	0.96 (0.72–1.29)	0.81 (0.61–1.08)	1.27 (0.85–1.92)
				Low	1.00 (0.80–1.26)	0.89 (0.67–1.19)	1.10 (0.81–1.48)	1.37 (0.89–2.09)
				Vitamin C
				High	Reference	0.79 (0.58–1.06)	Reference	1.33 (0.90–1.97)
				Middle	1.05 (0.86–1.28)	0.90 (0.68–1.19)	1.19 (0.89–1.59)	1.31 (0.87–1.98)
				Low	0.88 (0.70–1.10)	0.86 (0.64–1.15)	1.28 (0.92–1.77)	1.46 (0.94–2.27)
				Total tocopherol
				High	Reference	0.96 (0.71–1.30)	Reference	1.02 (0.72–1.42)
				Middle	1.02 (0.83–1.26)	0.85 (0.63–1.15)	0.96 (0.71–1.29)	1.36 (0.92–2.03)
				Low	0.96 (0.75–1.23)	0.82 (0.60–1.12)	1.21 (0.85–1.73)	1.55 (0.92–2.64)

CC will be translated into proline and GG will be translated into alanine. * star denotes p-value for interaction < 0.05.