Table 1.
The 23 factorial design and the composition of EGCG-loaded spanlastics.
| Formula | Variables | |||||
|---|---|---|---|---|---|---|
| Independent | Dependent | |||||
| X1 | X2 | X3 | Y1 * | Y2 * | Y3 * | |
| F1 | −1 | −1 | −1 | 88.04 ± 2.82 | 69.85 ± 1.33 | 263.6 ± 1.62 |
| F2 | −1 | −1 | 1 | 92.35 ± 1.34 | 62.39 ± 2.14 | 229.0 ± 1.54 |
| F3 | −1 | 1 | −1 | 70.53 ± 1.81 | 92.47 ± 1.28 | 318.8 ± 1.48 |
| F4 # | −1 | 1 | 1 | 80.56 ± 1.57 | 84.98 ± 1.33 | 243.8 ± 1.24 |
| F5 | 1 | −1 | −1 | 90.49 ± 1.22 | 74.97 ± 1.36 | 419.2 ± 1.82 |
| F6 | 1 | −1 | 1 | 97.93 ± 1.28 | 70.02 ± 1.25 | 304.5 ± 1.55 |
| F7 | 1 | 1 | −1 | 80.32 ± 1.38 | 94.52 ± 1.07 | 441.1 ± 2.03 |
| F8 | 1 | 1 | 1 | 89.99 ± 2.16 | 90.08 ± 1.46 | 377.0 ± 1.93 |
| Independent variables | Low (−1) | High (+1) | ||||
| X1: Ratio of Span to EA | 3:2 | 4:1 | ||||
| X2: Type of non-ionic surfactant | Span 60 | Span 80 | ||||
| X3: Type of EA | Tween 80 | Tween 60 | ||||
Notes: Y1: EE (%), Y2: Q12h (%), PS (nm), * the values are described as mean ± SD; all formulations involved 10 mg EGCG, n = 3, # optimized Formula. Abbreviations: EE, entrapment efficiency; Q12h, % drug released after 12 h; PS, Particle Size; EA, edge activator.