Table 8.
Effect of storage at 4–8 °C on the properties of the EGCG-loaded spanlastic formula (F4) and the corresponding niosomal formula.
| Parameter | Spanlastic Formula | Niosomal Formula | ||
|---|---|---|---|---|
| Fresh | Stored | Fresh | Stored | |
| Drug content (%) | 98.22 ± 1.21 | 97.98 ± 1. 14 | 99.14 ± 0.82 | 90.22 ± 1.60 |
| EE (%) | 80.56 ± 1.57 | 78.88 ± 1.18 | 69.84 ± 1.20 | 60.22 ± 1.57 |
| Q12h (%) | 84.98 ± 1.14 | 83.74 ± 0.88 | 97.11 ± 1.24 | 85.92 ± 1.37 |
| % drug permeated | 62.22 ±1.23 | 61.05 ± 1.33 | 50.22 ± 1.17 | 39.56 ± 1.22 |
| DI | 19.27 ±0.92 | 18.81 ± 0.72 | 1.48 ±0.12 | 0.69 ± 0.05 |
Notes: Each value is described as mean ± SD (n = 3); F4, the optimized EGCG-loaded spanlastics. Abbreviations: EE, entrapment efficiency; Q12h, % drug released after 12 h; DI, deformability index.