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. 2021 Jan 18;11(1):58. doi: 10.3390/jpm11010058

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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KEGG pathway enrichment analysis of upregulated genes by Fusobacterium nucleatum infection in human gingival fibroblasts. Gingival fibroblasts were infected with Fusobacterium nucleatum for 2, 6, 12, 24, and 48 h, and KEGG pathway analysis was performed. The color indicates the degree of statistical significance, and negative log10 of adjusted p values were presented in each box. Data were extracted and analyzed from the NCBI GEO profile database (GEO accession: GSE118691) [111]. Determination of upregulated genes at each time point was based on fold-change of the expression level > 2 and a p-value < 0.05.