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. 2021 Jan 18;22(2):904. doi: 10.3390/ijms22020904

Table 2.

Gain-of-function phenotypes induced by hSOD1. WT, wildtype.

Gal4 Line UAS Line Phenotype/Reference
D42-Gal4
(motoneurons)
hSOD1 WT No effect on lifespan, progressive motor dysfunction [74,75]
Abnormal synaptic transmission [74]
hSOD1 A4V No effect on lifespan, progressive motor dysfunction [74]
hSOD1 G85R No effect on lifespan, progressive motor dysfunction [74,75]
Abnormal synaptic transmission [74]
Induction of stress response in glial cells [74]
D42-Gal4
(motoneurons)
3 mM BMAA
(β-N-methylamino-l-alanine)
hSOD1 WT Increased lifespan compared to control flies [76]
hSOD1 A4V Increased lifespan compared to control flies [76]
hSOD1 G85R Increased lifespan compared to control flies [76]
M1B-Gal4
(glial cells)
3 mM BMAA
(β-N-methylamino-l-alanine)
hSOD1 WT Accelerated death compared to control flies [76]
hSOD1 A4V Accelerated death compared to control flies [76]
hSOD1 G85R Accelerated death compared to control flies [76]
24B-Gal4
(muscles)
hSOD1 WT No phenotype in thoracic muscle fibers,
Slight motor behavior defect and normal lifespan [77]
hSOD1 G93A Upheld wings, swollen mitochondria,
Impaired motor behavior and reduced lifespan [77]

This table describes the phenotypes associated with different UAS lines. Note that the experiments could be done at different temperatures.