Table 2.
Gain-of-function phenotypes induced by hSOD1. WT, wildtype.
| Gal4 Line | UAS Line | Phenotype/Reference |
|---|---|---|
| D42-Gal4 (motoneurons) |
hSOD1 WT | No effect on lifespan, progressive motor dysfunction [74,75] Abnormal synaptic transmission [74] |
| hSOD1 A4V | No effect on lifespan, progressive motor dysfunction [74] | |
| hSOD1 G85R | No effect on lifespan, progressive motor dysfunction [74,75] Abnormal synaptic transmission [74] Induction of stress response in glial cells [74] |
|
| D42-Gal4 (motoneurons) 3 mM BMAA (β-N-methylamino-l-alanine) |
hSOD1 WT | Increased lifespan compared to control flies [76] |
| hSOD1 A4V | Increased lifespan compared to control flies [76] | |
| hSOD1 G85R | Increased lifespan compared to control flies [76] | |
| M1B-Gal4 (glial cells) 3 mM BMAA (β-N-methylamino-l-alanine) |
hSOD1 WT | Accelerated death compared to control flies [76] |
| hSOD1 A4V | Accelerated death compared to control flies [76] | |
| hSOD1 G85R | Accelerated death compared to control flies [76] | |
| 24B-Gal4 (muscles) |
hSOD1 WT | No phenotype in thoracic muscle fibers, Slight motor behavior defect and normal lifespan [77] |
| hSOD1 G93A | Upheld wings, swollen mitochondria, Impaired motor behavior and reduced lifespan [77] |
This table describes the phenotypes associated with different UAS lines. Note that the experiments could be done at different temperatures.