Table 9.
Gain-of-function phenotypes induced by TBPH.
| Gal4 Line | Phenotype/Reference |
|---|---|
| Elav-Gal4 (pan-neuronal) | 100% lethality (90% at first instar larvae) [275] Semi-lethal [274] Lethal throughout development, larval locomotion defect, adult escapers with reduced lifespan and impaired climbing [266] |
| Elav-Gal4, Tubulin-Gal80TS (pan-neuronal, induced at adult stage) |
Climbing defect [288] |
| D42-Gal4 (motoneurons) | Impaired larval locomotion [265] Increased larval turning, weak motoneuronal death in LIII ventral ganglia [289] Lethal pupal stage [265,289] Lethal pupal/reduced lifespan depending on the dose [265] Age-dependent climbing defect [265,275] |
| D42-Gal4, Tubulin-Gal80TS (motoneurons, induced at adult stage) |
Weak reduction of neuron number in thoracic ganglia, reduced lifespan [301] |
| OK371-Gal4 (glutamatergic neurons) | Lifespan severely reduced [302] |
| OK371-Gal4/MARCM (individual leg motoneuron) |
Leg motor axon and NMJ degeneration [291] |
| Repo-Gal4 (pan-glial) | Premature lethality (prepupal stage) [270] |
| Mef2-Gal4 (muscles) | Irregular sarcomere (2nd instar larval stage), impaired larval locomotion, prepupal lethality [270] |
| GMR-Gal4 (eye) | Eye degeneration [270,274,289,292,302,303,304] 100% lethal at 29 °C [289] |
| EB1-Gal4 (ellipsoid body neurons) |
Impaired adult motor behavior, age-dependent axonal/synaptic degeneration, and loss of upper motoneuron [266] |
| Gal4221-Gal4 (sensory neurons) | Increased dendritic branching [274] |
| OK107-Gal4 (mushroom bodies) | Smaller axonal lobe, impaired learning ability [265] |
This table describes the Gal4 lines used to overexpress TBPH and the associated phenotypes/references.