Table 10.
Gain-of-function phenotypes induced by wildtype TDP-43.
| Gal4 Line | Phenotype/Reference |
|---|---|
| Act5C-Gal4 (ubiquitous) | Premature lethality [305] |
| Daughterless-Gal4 (ubiquitous) | Lethal pupal [306] |
| Elav-Gal4 (pan-neuronal) |
Embryonic lethal [306] L1 lethal [307] Reduced lifespan [305,308,309,310] Age progressive climbing deficit [309,311] |
| Elav-Gal4, Tubulin-Gal80TS (pan-neuronal, induced at adult stage) |
Premature lethality, reduced lifespan [305,307] Age progressive climbing deficit [312] |
| ElavGS (pan-neuronal, induced at adult stage) |
Reduced lifespan [307,313] Age progressive climbing deficit [314] |
| D42-Gal4 (motoneurons) |
Reduced survival, lethal at 2nd instar larval stage with high dose [315] Semi-lethal at 25 °C but viable at 18 °C, impaired climbing, no motoneuronal death in LIII ventral ganglia, motoneuronal death in adult thoracic ganglia [289] Larval locomotion defect [316] Increased larval turning [289,291,317,318,319] Age progressive climbing deficit [305,308,316,320,321] Reduced lifespan [293,313,318,320,322,323] |
| D42-Gal4, Tubulin- Gal80TS (motoneurons, induced at adult stage) |
Age progressive climbing deficit, reduced lifespan [324] |
| OK371-Gal4 (glutamatergic neurons) |
Lethal [306] Lethal pupal, motoneuron death in LIII [290] |
| OK371-Gal4/MARCM (individual leg motoneuron) |
Leg motor axon and NMJ degeneration [291] |
| RN2-Gal4 (sub-population of adult motoneurons) |
Age progressive climbing deficit [290] |
| Repo-Gal4 (pan-glial) |
Pupal lethal [307] Age progressive climbing deficit, reduced lifespan [309,325] Terminal deoxynucleotidyl tranferase (TdT) dUTP Nick-end labeling (TUNEL)-positive neural cells [309] Little loss of glial cells and neurons in adult brains [326] |
| Repo-Gal4, Tubulin-Gal80TS (pan-glial, induced at adult stage) |
Dramatic loss of glial cells associated to neuronal loss in adult brains [326] |
| 24B-Gal4 (muscles) | Lethal [306,307] |
| Mef2-Gal4 (muscles) | Lethal [306] |
| GMR-Gal4 (eye) |
Neurodegeneration [310,312,316,317,319,320,324,327,328,329] Age dependent progressive neurodegeneration [289,290,293,307,308,314,315,318,330,331,332,333,334] |
| GMR-Gal4, Tubulin-Gal80TS (eye, induced at adult stage) |
Age-dependent progressive neurodegeneration [293,312] |
| Gal4221-Gal4 (sensory neurons) |
Promoted dendritic branching [274] |
| OK107-Gal4 (mushroom bodies) |
No TUNEL-positive cells [309] Axonal loss and neuronal death (TUNEL-positive cells) [290] |
This table describes the Gal4 lines used to overexpress TDP43 and the associated phenotypes/references.