Table 11.
Gain-of-function phenotypes induced by TBPH or TDP-43 at larval neuromuscular junctions.
| Gal4 | TBPH or TDP-43 | Active Zone Number | Synaptic Boutons Number | Axonal Branch Number | Axonal Branch Length | Larval Locomotion |
|---|---|---|---|---|---|---|
| Elav-Gal4 (pan-neuronal) |
TDP-43 | nd | Decreased [316] | nd | nd | nd |
| D42-Gal4 (motoneurons) |
TBPH | nd | Increased [289] Decreased, dose dependent [265] |
Normal [289] Decreased, dose dependent [265] |
nd | Altered larval turning [289] Impaired, dose dependent [265] Normal [275] |
| TDP-43 | Increased [289] | Decreased [11,289,335,336] Normal [293] |
Decreased [11,289,335] | nd | Altered larval turning [289] Normal [293] |
|
| OK6-Gal4 (motoneurons) |
TBPH | nd | Increased [159] | nd | Increased [159] | nd |
| TDP-43 | nd | Increased [159] | nd | Increased [159] | nd | |
| OK371-Gal4 (glutamatergic neurons) |
TBPH | nd | Normal [302] | nd | nd | nd |
| TDP-43 | Normal [337] | Decreased [281,290] | Decreased [143] | Decreased [281] | Altered [281,290] | |
| Repo-Gal4 (pan-glial) |
TDP-43 | Normal [336] | Decreased [336] | nd | nd | Altered larval turning [336] |
This table describes the Gal4 lines used to overexpress TBPH or TDP-43 and the associated phenotypes/references at larval neuromuscular junctions (nd: not determined).