Table 12.
Comparison of phenotypes induced by gain of function of TDP-43 wildtype, mutated in the NLS or in the NES.
| GAL4 Line | TDP-43Ω | TDP-43NLSmut | TDP-43NESmut |
|---|---|---|---|
| Act5C-Gal4 (ubiquitous) | Lethal [305] | Lethal [305] | nd |
| Elav-Gal4 (pan-neuronal) |
L1 larval lethality [307] Viable, strong reduced life span [305] |
Pupal lethal [307] Viable, modest reduced life span [305] |
Pupal lethal, rare escapers [307] |
| ElavGS (pan-neuronal, induced at adult stage) |
Strong reduced lifespan [307] | Modest reduced lifespan [307] | Weak reduced lifespan [307] |
| D42-Gal4 (motoneurons) |
Age progressive climbing defect [321] | Strong age progressive climbing defect [321] | No climbing defect [321] |
| Repo-Gal4 (pan-glial) |
Pupal lethal [307] | Pupal lethal [307] | No effect [307] |
| 24B-Gal4 (muscles) | Larval lethal [307] | Embryonic lethal [307] | No effect [307] |
| GMR-Gal4 (eye) |
Modest degeneration [292,293,307,321,327] |
Strong degeneration [292,293,307,321,327] | No degeneration [292,307,321] |
This table describes the Gal4 lines used to overexpress the wildtype or NLS/NES mutant form of TDP-43 and the associated phenotypes/references.