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Immunofluorescence images of human umbilical vein endothelial cells (HUVEC)/cbMSC cell spheroids stained with antibodies against F-actin, fibronectin, and hypoxiainducible factors(HIF-1α). The results indicate that cell spheroids possessed the ECM molecule fibronectin and hypoxiaresponsive transcription factor HIF-1α. (Reproduced from Reference [112]).
