Table 4.

The relative AUC_(0–t) in rats after oral administration of CAT3 or SMEDDS.

Group	CAT3 in Plasma		Metabolite PF403 in Plasma
	AUC(0–t) ng/L·h	Relative AUC(0–t)(%)	AUC(0-t) ng/L·h	Relative AUC(0–t)(%)
CAT3	5.911 ± 0.396	100.00	20.537 ± 0.256	100.00
SMEDDS	10.564 ± 0.154 **	178.72	10.008 ± 0.677 **	48.73
CAT3 + Inhibition	1.862 ± 0.356 **	31.50	5.747 ± 0.333 **	29.98
SMEDDS + Inhibition	1.235 ± 0.166 ##	11.69 Note 1	5.542 ± 0.455 ## Note 1	55.38 Note 1

** p < 0.01 vs. CAT3-API, ^## p < 0.01 vs. CAT3-SMEDDS. Note 1: AUC _(0–t) ng/L·h vs. SMEDDS.