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. 2021 Jan 25;12:80. doi: 10.1186/s13287-020-02125-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Characterization of SKP-SC-derived EVs. a Representative TEM image of SKP-SC-EVs presenting a typical cup-like concavity shape. Scale bar, 200 nm. b Representative traces from nanoparticle tracking analysis for SKP-SC-EVs. c Western blots showing the positive expression of exosomal markers CD9, CD63, CD81, and TSG101 in EVs, and β-actin and S100β were used as control markers in SKP-SCs. d PKH67 labeled EVs (green) were showing within the cytoplasm and axon of TUJ1 positive sensory neurons (red), and nuclei were labeled with DAPI (blue). Scale bar, 30 μm