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. 2021 Jan 25;40:43. doi: 10.1186/s13046-021-01839-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Eicosanoids profiling in triple negative breast cancer (TNBC) reveals miR-155 positively correlates with PGE2/PGD2 ratio and related metabolic enzyme expression. a Expression-correlation analysis of miR-155 (in blue) and PGE2/PGD2 ratio (in red) measured in human TNBC specimens (n = 20). b-e Relative RNA expression of PTGES1(b), PTGES2(c), PTGDS(d) and 15-PGDH(e) in miR-155-high (H1-H10, in red) and miR-155-low (L1-L10, in blue) TNBC specimens (n = 20). f Western blot results of key metabolic enzymes and suggested novel regulators for PGE2/PGD2 metabolism in the miR-155-high and -low TNBC specimens. Results of COX1, COX2, PTGES1, PTGES2, PTGDS and 15-PGDH are shown. g, h Correlation analysis between miR-155 and PGE2(g) or PGD2(h) level in the plasma samples of TNBC patients