Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 25;40:43. doi: 10.1186/s13046-021-01839-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 3 — Modulation of miR-155 reprograms PGE2 and PGD2 production in human breast cancer cells, by the regulation of three prostaglandin synthases. a Relative PGE2 (left) and PGD2 (right) levels in MDA-MB-436 or Hs-578 T cells in control (in blue) or in miR-155-depleted cells (miRZIP155 in red). b The overexpression of miR-155 (miRH, in yellow) drives increased PGE2 (left) and decreased PGD2 (right) expression in MCF7 cells. c-f Relative RNA expression of Ptges1(c), Ptges2(d), Ptgds(e) and 15-Pgdh(f) in MDA-MB-436, Hs-578 T, and MCF7 cells after knockdown (miRZIP155, in red) or overexpression (miRH155, in yellow) of miR-155. g Western blot analysis of key metabolic enzymes for PGE2/PGD2 homeostasis, after knockdown (miRZIP155) or overexpression (miRH155) of miR-155 in three breast cancer cell lines