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. 2021 Jan 11;11:574167. doi: 10.3389/fgene.2020.574167

TABLE 2.

The top 10 up- and downregulated genes identified by RNA-Seq in FLHS chickens.

Genes log2FoldChange P-value P-adj Regulation Functions
OVCH2 2.42 7.3E-30 5.4E-26 Up Metabolism and transportation of amino acids
ANKRD22 3.56 1.2E-19 6.0E-16 Up Inflammatory response and apoptosis
ENSGALG00000005043 2.36 1.9E-15 7.1E-12 Up Cholesterol homeostasis and lipid metabolic process
SLC6A9 3.17 2.5E-15 7.4E-12 Up Neurotransmitter and amino acid transport
ENSGALG00000048882 2.61 5.3E-13 1.1E-09 Up /
NMRAL1 2.99 4.5E-10 6.7E-07 Up Immune response and apoptosis
IFI27L1 1.23 7.3E-10 9.8E-07 Up Apoptotic process
RASGRP3 2.08 1.4E-08 1.6E-05 Up Ras protein signal transduction and immune response
SLC38A1 1.43 1.6E-08 1.6E-05 Up Amino acid transporter and energy metabolism
ANGPTL4 1.25 6.6E-08 5.8E-05 Up Glucose and lipid metabolism
AOC1 −1.94 6.6E-41 9.8E-37 Down Lipid metabolism
ENSGALG00000044618 −1.71 7.9E-13 1.5E-09 Down /
PDE4D −2.07 8.0E-12 1.3E-08 Down Phosphodiesterase activity and inflammatory response
ADAMTS17 −1.94 7.0E-07 4.0E-04 Down Body fat distribution and metallopeptidase activity
VIL1 −1.83 3.0E-06 1.1E-03 Down Inflammatory response
FAH −1.44 5.1E-06 1.5E-03 Down Immune response and type II diabetes mellitus
PTPN20 −2.44 5.9E-06 1.7E-03 Down Proliferation, differentiation, migration, and survival
MICAL2 −1.38 6.1E-06 1.7E-03 Down Cell differentiation and migration and angiogenesis
NEBL −1.29 8.0E-06 2.1E-03 Down Organelle organization and tropomyosin binding
SPON2 −1.96 8.9E-06 2.3E-03 Down Immune responses