TABLE 2.
The top 10 up- and downregulated genes identified by RNA-Seq in FLHS chickens.
| Genes | log2FoldChange | P-value | P-adj | Regulation | Functions |
| OVCH2 | 2.42 | 7.3E-30 | 5.4E-26 | Up | Metabolism and transportation of amino acids |
| ANKRD22 | 3.56 | 1.2E-19 | 6.0E-16 | Up | Inflammatory response and apoptosis |
| ENSGALG00000005043 | 2.36 | 1.9E-15 | 7.1E-12 | Up | Cholesterol homeostasis and lipid metabolic process |
| SLC6A9 | 3.17 | 2.5E-15 | 7.4E-12 | Up | Neurotransmitter and amino acid transport |
| ENSGALG00000048882 | 2.61 | 5.3E-13 | 1.1E-09 | Up | / |
| NMRAL1 | 2.99 | 4.5E-10 | 6.7E-07 | Up | Immune response and apoptosis |
| IFI27L1 | 1.23 | 7.3E-10 | 9.8E-07 | Up | Apoptotic process |
| RASGRP3 | 2.08 | 1.4E-08 | 1.6E-05 | Up | Ras protein signal transduction and immune response |
| SLC38A1 | 1.43 | 1.6E-08 | 1.6E-05 | Up | Amino acid transporter and energy metabolism |
| ANGPTL4 | 1.25 | 6.6E-08 | 5.8E-05 | Up | Glucose and lipid metabolism |
| AOC1 | −1.94 | 6.6E-41 | 9.8E-37 | Down | Lipid metabolism |
| ENSGALG00000044618 | −1.71 | 7.9E-13 | 1.5E-09 | Down | / |
| PDE4D | −2.07 | 8.0E-12 | 1.3E-08 | Down | Phosphodiesterase activity and inflammatory response |
| ADAMTS17 | −1.94 | 7.0E-07 | 4.0E-04 | Down | Body fat distribution and metallopeptidase activity |
| VIL1 | −1.83 | 3.0E-06 | 1.1E-03 | Down | Inflammatory response |
| FAH | −1.44 | 5.1E-06 | 1.5E-03 | Down | Immune response and type II diabetes mellitus |
| PTPN20 | −2.44 | 5.9E-06 | 1.7E-03 | Down | Proliferation, differentiation, migration, and survival |
| MICAL2 | −1.38 | 6.1E-06 | 1.7E-03 | Down | Cell differentiation and migration and angiogenesis |
| NEBL | −1.29 | 8.0E-06 | 2.1E-03 | Down | Organelle organization and tropomyosin binding |
| SPON2 | −1.96 | 8.9E-06 | 2.3E-03 | Down | Immune responses |