TABLE 4.

Top canonical pathways that are enriched by differentially peak–genes between FLHS-affected and non-affected chickens.

ID	Pathways	P-value	Associated peak–genes	Regulated	Function
hsa03320	PPAR signaling pathway	3.58E-03	APOA1, FABP1, PCK1, and ANGPTL4	Up	It involved in several physiological processes including modulation of cellular differentiation; development; metabolism of carbohydrates, lipids, and proteins; and tumorigenesis
hsa04975	Fat digestion and absorption	1.40E-02	APOA4, APOA1, and FABP1	Up	It is essential in the prevention of a calorie balance disorder and improving the pathological conditions of metabolic syndrome through improvement of obesity
hsa04151	PI3K-Akt signaling pathway	1.59E-02	LAMA4, FGF7, PDGFRA, PDGFD, and KIT	Down	It is critical in restricting pro-inflammatory and promoting anti-inflammatory responses in TLR-stimulated macrophages and has been considered as a negative regulator of TLR and NF-κB signaling in macrophages
hsa04015	Rap1 signaling pathway	2.18E-02	FGF7, PDGFRA, PDGFD, and KIT	Down	It plays a dominant role in the control of cell–cell and cell–matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types
hsa04010	MAPK signaling pathway	3.53E-02	FGF7, NTF3, NTRK2, and PDGFRA	Down	It is essential in regulating many cellular processes including inflammation, cell stress response, cell differentiation, cell division, cell proliferation, metabolism, motility, and apoptosis