TABLE 5.
Interested genes enriched in pathways which related with lipid metabolic, glucose homeostasis, and immune processes, etc.
| Gene | Symbol | FoldChange | P-value | H3K27ac peak | Correlation | Regulated | Function |
| PCK1 | Phosphoenolpyruvate carboxykinase 1 | 7.90 | 4.9E-02 | Chr20:11003689-11003961 | 0.890 | Up | This gene is a main control point for the regulation of gluconeogenesis and the expression can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet |
| APOA1 | Apolipoprotein A1 | 3.09 | 2.9E-02 | Chr24:5089487-5090379 | 0.887 | Up | The encoded preproprotein promotes cholesterol efflux from tissues to the liver for excretion and is a cofactor for lecithin cholesterol acyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters |
| ANGPTL4 | Angiopoietin-like 4 | 2.38 | 6.6E-08 | Chr28:1779594-1787257 | 0.983 | Up | This gene encodes a glycosylated, which functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity |
| FABP1 | Fatty acid binding protein 1 | 2.04 | 1.7E-03 | Chr4:86731254-86735175 | 0.929 | Up | This gene encodes the fatty acid binding protein found in the liver and plays an essential role in fatty acid uptake, transport, and metabolism |
| NTRK2 | Neurotrophic receptor tyrosine kinase 2 | 7.21 | 1.1E-02 | ChrZ:41171358-41171800 | 0.902 | Down | This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family and associates with obesity and mood disorders |
| FGF7 | Fibroblast growth factor 7 | 5.55 | 2.0E-02 | Chr10:11491528-11493116 | 0.974 | Down | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family and involves in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion |
| PDGFRA | Platelet-derived growth factor receptor alpha | 2.85 | 9.4E-04 | Chr4:65059385-65060498 | 0.864 | Down | This gene plays a role in organ development, wound healing, and tumor progression |
| KIT | Receptor tyrosine kinase | 2.48 | 3.7E-02 | Chr4:65997303-65998627 | 0.892 | Down | It encodes a tyrosine kinase receptor and is part of signaling pathways that control multiple cellular processes, including cell proliferation, survival, and migration |