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. 2021 Jan 11;11:575762. doi: 10.3389/fgene.2020.575762

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Copyright © 2021 Chen, Wu, Lu, Hu, Li, Huang, Zhang, Chen, Qin and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The expression of the hub genes was validated in HCC tissues. (A) The mRNA expression patterns of hub genes in the Oncomine database. This figure shows the numbers of datasets with statistically significant mRNA overexpression (red) or under-expression (blue) of the target gene (cancer vs. normal). The p value threshold is 0.0001. The number in each cell represents the number of analyses that met the threshold within the analyses and cancer types. The mRNA expression levels of (B) TOP2A, (C) CCNB2, (D) PRC1, (E) RACGAP1, (F) AURKA, (G) CDKN3, (H) NUSAP1, (I) CDCA5, (J) ASPM, and (K) NCAPG in LIHC tissues and normal liver tissues using GEPIA2. *p < 0.01 was considered statistically significant. HCC, hepatocellular carcinoma; LIHC, liver hepatocellular carcinoma. The “Yellow Box” specified the mRNA expression of these hub genes in liver cancer.