Table 2.
Alpha-smooth muscle actin staining scores of renal biopsy tissues sampled repeatedly from 6 PSAGN patients and their characteristics.
Patient Age (Years) | Acute Phase: Duration between Onset to First Biopsy (Days) | Convalescent Phase: Duration between Onset to Second Biopsy (Years) | Glomerular Staining Score | Interstitial Staining Score | |||
---|---|---|---|---|---|---|---|
First Biopsy | Second Biopsy | First Biopsy | Second Biopsy | ||||
Progression into CKD (n = 3) | 39.3 ± 6.0 | 19.7 ± 9.9 | 3.0 ± 1.0 | 2.7 ± 1.2 | 0.7 ± 0.6 | 3.7 ± 0.6 | 3.0 ± 1.0 |
Cured (n = 3) |
35.7 ± 7.8 | 23.3 ± 12.1 | 5.1 ± 4.5 | 3.0 ± 1.0 | 0.7 ± 0.6 | 2.7 ± 0.6 | 1.7 ± 0.6 |
PSAGN: poststreptococcal acute glomerulonephritis; CKD: chronic kidney disease. Data are expressed as the mean ± SD. Sections stained for α-SMA as described in Figure 4 were evaluated as follows. Glomerular staining intensities were semiquantitatively graded as 0 to 4, as previously reported by Alpers et al. [48], whereas interstitial staining intensities were graded semiquantitatively as 1 to 4 using the following scale: 1 = positive area < 10%; 2 = 10% to 20%; 3 = 20% to 30%; 4 ≥ 30%.