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. 2021 Jan 18;22(2):913. doi: 10.3390/ijms22020913
ADAMTS A disintegrin-like and metalloprotease domain with thrombospondin type 1 motifs ALPAlkaline Phosphatase
AS aortic stenosis
BMP bone morphogenetic protein
CAVD calcific aortic valve disease
ECM extracellular matrix
EMT epithelial-mesenchymal transition
EndMT endothelial-mesenchymal transition
EVs extracellular vesicles
GAGs glycosaminoglycans
HA hyaluronic acid
HIF-1α hypoxia inducible factor-1 α
ICAM-1 intercellular adhesion molecule 1
LOX lysyl oxidase
LPS lipopolysaccharides
MMPs matrix metalloproteinases
Msx2 MshHomeobox 2
MVs matrix vesicles
NGAL neutrophil gelatinase-associated lipocalin
PCSK9 proprotein convertase subtilisin/kexin type 9
PGC-1α peroxisome proliferator-activated receptor-γ coactivator 1-α
PGs proteoglycans
PO periostin
RHAMM receptor for hyaluronate-mediated motility
RUNX2 runt-related transcription factor 2
SMCs smooth muscle cells
TAVI trans-catheter aortic valve implantation
TAVR trans-catheter aortic valve replacement
TGF-β transforming growth factor-β
TIMPs tissue inhibitors of metalloproteinases
TNC tenascin-C
TSG-6 TNF-α stimulated gene-6
VECs vascular endothelial cells
VEGF vascular endothelial growth factor
VICs vascular interstitial cells
α-SMA α-smooth muscle actin