Table 4.
Cox proportional hazard regression analysis shows pre and even more pronounced the postsurgical KPS, interval between tumor diagnosis and brain metastases (BM) detection, adjuvant radiation and systemic treatment as independent prognostic factors for overall survival in the elderly population.
| Parameter | Hazard Ratio | 95% CI | p-Value | |
|---|---|---|---|---|
| Interval tumor diagnosis BM | 0.996 | 0.993 | 0.999 | 0.040 |
| Metastasis timing | 0.811 | 0.632 | 1.041 | 0.101 |
| Presurgical Karnofsky performance status | 0.989 | 0.980 | 0.999 | 0.041 |
| Postsurgical Karnofsky performance status | 0.983 | 0.975 | 0.992 | 0.0001 |
| Postsurgical radiation | 0.753 | 0.580 | 0.978 | 0.034 |
| Postsurgical systemic treatment | 0.636 | 0.509 | 0.795 | 0.0001 |
| Tumor location | 1.041 | 0.985 | 1.110 | 0.133 |