Table 1.
Median and mean concentrations of RBC, reticulocyte, total WBC and PLT counts in NSG male and female mice measured with a IDEXX ProCyte Dx and a Sysmex XT-2000iV analyzer (data for C57BL6 mice are given for comparison).
| ANOVA p |
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| Variable (unit) | n | A | Analyzer | Gender | Median (range) | Mean (SD) | C57 BL/6J39 Median (range) |
| RBC-I (1012/L) | 20m+20f | P/S | 0.074 | <0.001 | 8.26 (7.02–9.09) | 8.27 (0.38) | 9.11 (7.75–9.61) |
| 20m | 8.38 (8.13–9.09) | 8.47 (0.30) | |||||
| 20f | 8.09 (7.02–8.54) | 8.07 (0.34) | |||||
| RBC-O (1012/L) | 20m+20f | P | <0.001 | <0.001 | 8.40 (7.10–9.20) | 8.40 (0.41) | 9.545 (8.25–10.33) |
| 20m | 8.56 (8.13–9.20) | 8.61 (0.35) | |||||
| 20f | 8.25 (7.10–8.84) | 8.20 (0.36) | |||||
| 20m+20f | S | 7.90 (6.77–8.67) | 7.90 (0.35) | ||||
| 20m | 8.15 (7.53–8.67) | 8.07 (0.30) | |||||
| 20f | 7.73 (6.77–8.23) | 7.72 (0.30) | |||||
| HGB (g/L) | 20m+20f | P/S | 0.496 | <0.001 | 135.8 (121.0–149.5) | 135.9 (5.5) | 131.0 (122–139) |
| 20m | 137.0 (131.5–149.5) | 137.9 (5.0) | |||||
| 20f | 135.0 (121.0–141.5) | 133.6 (5.2) | |||||
| Hct (L/L) | 20m+20f | P | <0.001 | <0.001 | 0.446 (0.393–0.497) | 0.446 (0.022) | 0.4255 (0.38–0.45) |
| 20m | 0.459 (0.429–0.497 | 0.460 (0.018) | |||||
| 20f | 0.437 (0.393–0.463) | 0.435 (0.018) | |||||
| 20m+20f | S | 0.421 (0.378–0.459) | 0.419 (0.019) | ||||
| 20m | 0.435 (0.409–0.459) | 0.433 (0.013) | |||||
| 20f | 0.406 (0.378–0.427) | 0.406 (0.014) | |||||
| MCV (fL) | 20m+20f | P | <0.001 | 0.011 | 53.7 (51.6–56.5) | 53.7 (1.1) | 46.5 (46.0–49.8) |
| 20m | 54.1 (51.8–56.5) | 54.0 (1.2) | |||||
| 20f | 53.5 (51.6–55.8) | 53.5 (0.9) | |||||
| 20m+20f | S | 51.0 (49.2–54.1) | 51.1 (1.1) | ||||
| 20m | 51.6 (49.7–54.0) | 51.5 (1.1) | |||||
| 20f | 50.7 (49.2–54.1) | 50.7 (1.0) | |||||
| MCH (pg) | 20m+20f | P | 0.005 | <0.001 | 16.3 (15.9–17.2) | 16.4 (0.3) | 14.5 (14.1–16.0) |
| 20m | 16.3 (15.9–16.9) | 16.3 (0.2) | |||||
| 20f | 16.4 (16.1–17.2) | 16.6 (0.3) | |||||
| 20m+20f | S | 16.5 (16.0–17.3) | 16.5 (0.3) | ||||
| 20m | 16.3 (16.0–16.8) | 16.4 (0.2) | |||||
| 20f | 16.6 (16.3–17.3) | 16.7 (0.3) | |||||
| MCHC (g/L) | 20m+20f | P | <0.001 | <0.001 | 305.0 (290-315) | 304.6 (5.1) | 311 (304–327) |
| 20m | 301.5 (290–310) | 301.9 (4.7) | |||||
| 20f | 307.0 (299–315) | 307.3 (4.2) | |||||
| 20m+20f | S | 324.0 (306–334) | 323.4 (7.4) | ||||
| 20m | 316.5 (306–327) | 317.7 (5.3) | |||||
| 20f | 330.0 (320–334) | 329.2(3.9) | |||||
| RDW-SD (fL) | 20m+20f | P | <0.001 | 0.652 | 30.4 (28.4–34.6) | 30.5 (1.1) | 29.7 (27.4–31.0) |
| 20m+20f | S | 29.6 (27.8–33.8) | 29.7 (1.0) | ||||
| RDW-CV (%) | 20m+20f | P | <0.001 | 0.535 | 21.4 (20.6–22.4) | 21.5 (0.5) | 24.3 (20.1–25.2) |
| 20m+20f | S | 18.8 (18.2-20.0) | 18.9 (0.4) | ||||
| RBC-HGB (pg) | 20m+20f | P | <0.001 | 0.003 | 18.0 (17.7–18.9) | 18.1 (0.3) | |
| 20m | 18.0 (17.8–18.3) | 18.0 (0.2) | |||||
| 20f | 18.2 (17.7–18.9) | 18.2 (0.3) | |||||
| 20m+20f | S | 17.2 (16.7–18.0) | 17.2 (0.3) | ||||
| 20m | 17.2 (16.7–17.4) | 17.1 (0.2) | |||||
| 20f | 17.2 (16.9–18.0) | 17.3 (0.3) | |||||
| RET (109/L) | 19ma+20f | P/S | 0.444 | 0.127 | 469 (296–673) | 483 (76) | 307.5 (241.8–368.1) |
| RET (%) | 20m+19fb | P/S | 0.360 | 0.022 | 5.70 (3.81–8.25) | 5.82 (0.90) | 3.41 (2.97–3.83) |
| 20m | 5.62 (4.94–6.18) | 5.63 (0.35) | |||||
| 19fb | 5.80 (3.81–8.25) | 6.02 (1.22) | |||||
| IRF(%) | 20m+20f | P | <0.001 | 0.846 | 61.1 (54.0–70.1) | 61.0 (3.5) | 52.9 (50.4–56.9) |
| 20m+20f | S | 45.2 (37.9–55.8) | 45.4 (3.4) | ||||
| LRF(%) | 20m+20f | P | <0.001 | 0.139 | 39.0 (29.9–46.0) | 39.0 (3.5) | 47.2 (43.1–49.6) |
| 20m+20f | S | 20.1 (17.3–22.9) | 20.3 (1.5) | ||||
| MRF(%) | 20m+20f | P | <0.001 | 0.325 | 17.0 (12.3–20.0) | 16.7 (1.7) | 20.0 (16.9–23.2) |
| 20m+20f | S | 43.2 (24.8–43.6) | 34.4 (4.0) | ||||
| HRF(%) | 20m+20f | P | <0.001 | 0.371 | 44.3 (34.0–55.5) | 44.3 (4.2) | 33.35 (27.7–37.3) |
| 20m+20f | S | 54.9 (44.2–62.1) | 54.7 (3.4) | ||||
| Ret-HGB(pg) | 20m+20f | P | <0.001 | <0.001 | 18.8 (18.3–20.2) | 18.9 (0.4) | |
| 20m | 18.7 (18.3–18.9) | 18.7 (0.2) | |||||
| 20f | 19.0 (18.5–20.2) | 19.1 (0.5) | |||||
| 20m+20f | S | 20.0 (19.4–21.6) | 20.1 (0.5) | ||||
| 20m | 19.9 (19.4–20.1) | 19.8 (0.2) | |||||
| 20f | 20.1 (19.6–21.6) | 20.3 (0.5) | |||||
| WBC (109/L) | 20m+17fc | P/S | 0.881 | <0.001 | 1.11 (0.42–2.60) | 1.23 (0.5) | 6.0 (4.0–10.9) |
| 20m | 0.93 (0.42–1.24) | 0.9 (0.2) | |||||
| 17fc | 1.56 (0.88–2.60) | 1.59 (0.49) | |||||
| PLT-I (109/L) | 17m+19f | P | <0.001 | 0.007 | 979 (798–1189) | 974 (93) | 1006 (853–1951) |
| 17m | 1001 (907–1189) | 1015 (74) | |||||
| 19f | 959 (798–1097) | 937 (95) | |||||
| 17m+19f | S | 0.115 | 1733 (1247–1990) | 1733 (167) | |||
| PLT-O (109/L) | 17m+19f | P | <0.001 | <0.001 | 1212 (930–1392) | 1213 (125) | 1107 (878–2283) |
| 17m | 1258 (1146–1392) | 1273 (71) | |||||
| 19f | 1092 (930–1255) | 1101 (105) | |||||
| 20m+20f | S | <0.001 | 1576 (1090–1845) | 1532 (191) | |||
| 17m | 1658 (1090–1845) | 1629 (170) | |||||
| 19f | 1410 (1199–1733) | 1435 (163) | |||||
| MPV (fL) | 17m+19f | P | <0.001 | 0.339 | 6.1 (5.8–6.4) | 6.1 (0.2) | 5.7 (5.3–6.1) |
| 20m+20f | S | 0.004 | 6.6 (6.3–7.0) | 6.6 (0.2) | |||
| 17m | 6.6 (6.3–6.8) | 6.5 (0.2) | |||||
| 19f | 6.7 (6.5–7) | 6.7 (0.1) | |||||
| PCT (mL/L) | 17m+19f | P | <0.001 | 0.007 | 6.0 (4.8–7.3) | 6.0 (0.6) | 5.7 (4.8–11.0) |
| 17m | 6.3 (5.4–7.3) | 6.2 (0.5) | |||||
| 19f | 5.7 (4.8–6.8) | 5.8 (0.6) | |||||
| 20m+20f | S | 0.377 | 11.6 (8.4–13.3) | 11.5 (1.1) | |||
| PDW (fL) | 17m+19f | P/S | 0.092 | 0.340 | 6.8 (6.5–7.4) | 6.8 (0.2) | 6.5 (6.2–7.2) |
Corresponding reference intervals are given as supplementary tables
P: ProCyte Dx analyzer; S: XT-2000iV analyzer; m: males; f: females; SD: standard deviation; outliers deleted: a: 965 109/L; b:13.8%; c: 4.89; 4.35; 3.57 109/L