Table 3.
Median and mean concentrations of biochemical analytes measured by the VetScan VS2 analyzer in NSG male and female mice.
| Variable (unit) | n | ANOVA P Gender | Median (range) | Mean (SD) | C57 BL/6J 3 Median (range) | |
| Sodium (mmol/L) | 20m+17f | 0.007 | 145.0 (142–154) | 145.5 (2.2) | ||
| 20m | 146.0 (143–154) | 146.4 (2.5) | 155 (149–165) | |||
| 17f | 144.0 (142–147) | 144.4 (1.3) | 158 (147–163) | |||
| Potassium (mmol/L) | 19m§+17f | 0.074 | 4.8 (3.7–6.3) | 4.8 (0.5) | 4.30 (3–6.2) (m) | |
| 4.60 (3.5–5.1)(f) | ||||||
| Calcium (mmol/L) | 20m+17f | <0.001 | 2.43 (2.23–2.75) | 2.43 (0.12) | ||
| 20m | 2.49 (2.43–2.75) | 2.52 (0.11) | 2.04 (1.87–2.34) | |||
| 17f | 2.35 (2.23–2.50) | 2.36 (0.07) | 2.06 (1.78–2.30) | |||
| Phosphate (mmol/L) | 20m+14fa | 0.022 | 2.1 (1.6–2.5) | 2.1 (0.2) | ||
| 20m | 2.0 (1.6–2.5) | 2.0 (0.3) | ||||
| 14fa | 2.2 (1.9–2.5) | 2.2 (0.1) | ||||
| Glucose (mmol/L) | 20m+17f | 0.003 | 14.4 (11.5–19.0) | 14.6 (1.9) | ||
| 20m | 15.5 (12.4–19.0) | 15.4 (1.9) | 8.3 (2.6–16.3) | |||
| 17f | 13.6 (11.5–16.3) | 13.7 (1.4) | 9.9 (5.7–16.9) | |||
| Urea (mmol/L) | 20m+17f | 0.107 | 7.8 (6.4–10.7) | 8.0 (1.0) | 9 (2.8–13.3)(m) | |
| 8.7 (5.7–11.7) (f) | ||||||
| Creatinine (µmol/L) | 20m+17f | 0.278 | <10 (<10–35) | — | 17 (10–29) (m) | |
| 15 (11–28) (f) | ||||||
| Bilirubin (µmol/L) | 19m§+17f | 0.012 | 5 (3–9) | 6 (1) | ||
| 19m§ | 7 (3–7) | 6 (1) | 5.1 (<1.7–8.6) | |||
| 17f | 5 (3v9) | 5 (3-9) | 6.8 (1.7–15.4) | |||
| Proteins (g/L) | 20m+17f | 0.001 | 48.0 (43–55) | 48.0 (2.3) | ||
| 20m | 49.0 (47–55) | 49.1 (2.2) | 40 (20–60) | |||
| 17f | 46.0 (43–50) | 46.7 (1.6) | 40 (30–50) | |||
| Albumin (g/L) | 20m+17f | 0.538 | 34.0 (30–39) | 34.2 (2.0) | ||
| Globulins (g/L) | 20m+17f | <0.001 | 14.0 (10–18) | 13.7 (2.4) | ||
| 20m | 15.0 (12–18) | 15.0 (1.2) | ||||
| 17f | 11.0 (10–17) | 12.2 (2.6) | ||||
| ALT (U/L) | 19mb+17f | 26.0 (19–32) | 25.9 (3.1) | |||
| 19mb | 0.011 | 27.0 (23–32) | 27.1 (2.9) | 21 (13–39) | ||
| 17f | 25.0 (19–29) | 24.6 (2.8) | 22 (12–44) | |||
| ALP (U/L) | 20m+17f | <0.001 | 80.0 (45–126) | 83.1(19.6) | ||
| 20m | 74.5 (45–98) | 71.2 (13.6) | 153 (63-221) | |||
| 17f | 100.0 (69–126) | 97.1 (16.1) | 129 (44–235) | |||
| Amylase (U/L) | 20m+17f | <0.001 | 961 (735–1297) | 960 (146) | ||
| 20m | 1065 (906–1297) | 1073 (93) | 1942 (1501–3084) | |||
| 17f | 832 (735–936) | 829 (59) | 1940 (1157–2762) |
m: males; f: females; SD: standard deviation; Outliers deleted a: 1.6; 2.9; 2.9 mmol/L; b: 39 U/L; §: Value missing due to technical errors.
Corresponding reference intervals are provided as supplementary tables.