Table 3.
Characteristics of Patients 18 Years and Older Hospitalized With COVID-19, Overall and by ICU Status, Mayo Clinic, March Through July 2020
| Characteristic | Total (N=897) | ICU (N=354) | Unadjusted Model |
Multivariable Model |
|||
|---|---|---|---|---|---|---|---|
| OR | 95% CI | OR | 95% CI | P | |||
| Demographic variables | |||||||
| Age (y), median (range) | 59 (18-99) | 59.5 (20-99) | |||||
| Age distribution (y), no. (%) | |||||||
| 18-34 | 107 (11.9%) | 28 | 1 | Reference | 1 | Reference | |
| 35-49 | 164 (18.3%) | 69 | 2.05 | 1.21-3.52 | 2.32 | 1.04-5.20 | .04 |
| 50-64 | 284 (31.7%) | 123 | 2.16 | 1.33-3.57 | 2.33 | 0.95-5.73 | .07 |
| 65-74 | 157 (17.5%) | 70 | 2.27 | 1.34-3.91 | 2.06 | 0.76-5.58 | .16 |
| ≥75 | 185 (20.6%) | 64 | 1.49 | 0.89-2.55 | 1.49 | 0.55-4.06 | .43 |
| Sex, no. (%) | |||||||
| Female | 406 (45.3%) | 157 | 1 | Reference | 1 | Reference | |
| Male | 491 (54.7%) | 197 | 1.06 | 0.81-1.39 | 0.84 | 0.55-1.30 | .43 |
| Race/ethnicity, no. (%) | |||||||
| Hispanic (all races) | 169 (18.8%) | 65 | 1.05 | 0.73-1.51 | 1.64 | 0.97-2.77 | .07 |
| White, non-Hispanic | 481 (53.6%) | 179 | 1 | Reference | 1 | Reference | |
| Black, non-Hispanic | 90 (10.0%) | 48 | 1.93 | 1.23-3.04 | 1.34 | 0.65-2.76 | .43 |
| Asian, non-Hispanic | 50 (5.6%) | 23 | 1.44 | 0.79-2.58 | 2.84 | 1.33-6.08 | .007 |
| All other, non-Hispanic | 107 (11.9%) | 39 | 0.97 | 0.62-1.49 | 1.16 | 0.58-2.29 | .68 |
| Month of COVID-19 diagnosis, no. (%) | |||||||
| March | 49 (5.5%) | 23 | 1 | Reference | 1 | Reference | |
| April | 79 (8.8%) | 35 | 0.90 | 0.44-1.84 | 0.97 | 0.38-2.50 | .95 |
| May | 118 (13.2%) | 51 | 0.86 | 0.44-1.69 | 1.63 | 0.67-3.95 | .28 |
| June | 301 (33.6%) | 91 | 0.49 | 0.27-0.91 | 0.53 | 0.23-1.22 | .14 |
| July | 350 (39.0%) | 154 | 0.89 | 0.49-1.63 | 0.63 | 0.27-1.44 | .27 |
| Comorbidity and lifestyle | |||||||
| CCI score, median (range) | 3 (0-19) | 3 | — | ||||
| CCI score, no. (%) | |||||||
| 0 | 164 (18.3%) | 58 | 1 | Reference | 1 | Reference | |
| 1 | 117 (13.0%) | 50 | 1.36 | 0.84-2.22 | 1.02 | 0.44-2.40 | .96 |
| ≥2 | 616 (68.7%) | 246 | 1.22 | 0.85-1.75 | 0.97 | 0.44-2.18 | .95 |
| Body mass index (kg/m2), no. (%) | |||||||
| <18.5 | 10 (1.1%) | 4 | 1.23 | 0.30-4.47 | |||
| 18.5-24.9 | 159 (17.7%) | 56 | 1 | Reference | |||
| 25.0-29.9 | 238 (26.5%) | 94 | 1.20 | 0.79-1.83 | |||
| 30.0-39.9 | 324 (36.1%) | 130 | 1.23 | 0.83-1.83 | |||
| ≥40 | 132 (14.7%) | 58 | 1.44 | 0.90-2.32 | |||
| Missing | 34 (3.8%) | 12 | 1.00 | 0.45-2.15 | |||
| Smoking, no. (%) | |||||||
| Never | 545 (60.8%) | 207 | 1 | Reference | |||
| Former | 240 (26.8%) | 99 | 1.15 | 0.84-1.56 | |||
| Current | 84 (9.4%) | 35 | 1.17 | 0.73-1.86 | |||
| Missing | 28 (3.1%) | 13 | 1.42 | 0.65-3.04 | |||
| Laboratory results (admission), no. (%) | |||||||
| Platelets | |||||||
| Low | 238 (26.5%) | 89 | 0.89 | 0.65-1.21 | |||
| Normal range | 608 (67.8%) | 244 | 1 | Reference | |||
| High | 39 (4.3%) | 18 | 1.28 | 0.66-2.45 | |||
| Missing | 12 (1.3%) | 3 | |||||
| Aspartate aminotransferase, no. (%) | |||||||
| Normal range | 447 (53.9%) | 161 | 1 | Reference | 1 | Reference | |
| Elevated | 382 (46.1%) | 179 | 1.57 | 1.19-2.07 | 2.12 | 1.42-3.15 | <.001 |
| Missing | 68 | 14 | |||||
| Alanine aminotransferase, no. (%) | |||||||
| Normal range | 606 (73.2%) | 244 | 1 | Reference | |||
| Elevated | 222 (26.8%) | 96 | 1.13 | 0.83-1.54 | |||
| Missing | 69 | 14 | |||||
| Bilirubin, no. (%) | |||||||
| Normal range | 799 (96.3%) | 325 | 1 | Reference | |||
| Elevated | 31 (3.7%) | 16 | 1.56 | 0.76-3.22 | |||
| Missing | 67 | 13 | |||||
| Creatinine, no. (%) | |||||||
| Normal range | 563 (64.1%) | 211 | 1 | Reference | 1 | Reference | |
| Elevated | 315 (35.9%) | 143 | 1.39 | 1.05-1.84 | 1.66 | 1.04-2.64 | .03 |
| Missing | 19 | 0 | |||||
| Neutrophil-lymphocyte ratio, no. (%) | |||||||
| <6 | 427 (57.0%) | 126 | 1 | Reference | 1 | Reference | |
| ≥6 | 322 (43.0%) | 147 | 2.01 | 1.48-2.72 | 3.06 | 2.05-4.56 | <.001 |
| Missing | 148 | 81 | |||||
CCI, Charlson Comorbidity Index; COVID-19, coronavirus disease 2019; ICU, intensive care unit; OR, odds ratio.