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. 2021 Jan 13;556:79–86. doi: 10.1016/j.virol.2021.01.002

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© 2021 Published by Elsevier Inc.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 4 — Prognostic value of the CD8+:B cells ratio. A) Correlation analysis revealed a positive correlation of activated CD8⁺ expressing CD38⁺ and HLADR (CD38+HLADR + CD8⁺) and outcome (duration of hospitalisation) (i), an inverse correlation of the ratio of CD8+:B cells with ii) outcome iii) C-reactive protein iv) IL-6 v) neutrophil total count and a positive correlation with Natural Killer-like T cells (vi). B). A significant decrease of the ratio of CD8+:B cells was observed between non-intubated and intubated (i) as well as between intubated survivors versus non-survivors (ii). Statistical analysis was performed by Mann-Whitney U test or Wilcoxon test. *p < 0.05. C) Receiving operating curve analysis of CD8+:B cells in predicting poor prognosis as the requirement of mechanical ventilation. AUC = 0.7477, Standard error = 0.0729, 95% Confidence interval; 0.5922 to 0.9031, p = 0.007. cut-off = 1.323, sensitivity = 81.48%, specificity = 68.77%, likelihood ratio = 2.607.