Table 1.
IC50 values of the studied compounds on the diphenolase activity of mushroom tyrosinase.
| Compound | IC50 1 (µM) | 95% CI 2 IC50 (µM) (n = 3) |
Ratio of IC50 of Kojic Acid to IC50 of TSC |
|---|---|---|---|
| TSC 1 | 12.2 | 10.3–14.8 | 1.6 |
| TSC 2 | 1.9 | 1.7–2.5 | 10.5 |
| TSC 3 | 1.8 | 1.3–2.1 | 11.1 |
| TSC 4 | 11.3 | 9.9–12.7 | 1.8 |
| TSC 5 | 0.65 | 0.5–0.7 | 30.6 |
| TSC 6 | 0.34 | 0.3–0.4 | 58.5 |
| TSC 7 | 1.2 | 1.0–1.2 | 16.5 |
| TSC 8 | 0.95 | 0.8–1.0 | 20.9 |
| TSC 9 | 0.80 | 0.7–0.9 | 24.9 |
| TSC 10 | 154,5 | 106.4–224.3 | 0.1 |
| TSC 11 | 14.2 | 12.91–15.79 | 1.4 |
| TSC 12 | 1.6 | 1.622–2.115 | 12.4 |
| Benzaldehyde TSC | 3.4 | 2.9–4.0 | 5.6 |
| Acetophenone TSC | 1.5 | 1.3–1.7 | 13.2 |
| Kojic acid | 19.9 | 17.2–23.9 | 1.0 |
1 Inhibitor concentration required for 50% inhibition; 2 confidence interval.