Table 3.
Effectiveness of TSCs in inhibition of melanin production and B16F10 cell proliferation.
| Compound | Inhibition of Melanin Production | 95% CI 2 IC50 (µM) | Inhibition of Cell Proliferation | 95% CI 2 IC50 (µM) |
|---|---|---|---|---|
| IC50 1 (µM) | IC50 1 (µM) | |||
| TSC 1 | 39.2 | 36.57–42.03 | 45.2 | 36.43–56.19 |
| TSC 2 | 13.5 | 12.45–14.68 | 22.4 | 17.15–29.35 |
| TSC 3 | 13.1 | 11.68–14.65 | 20.3 | 15.03–27.35 |
| TSC 4 | 207.8 | 135.2–319.6 | 3113.4 3 | 499.3–19414 |
| TSC 5 | 88.9 | 81.41–97.12 | 149.6 | 124.8–179.4 |
| TSC 6 | 139.4 | 126.3–153.9 | 154.9 | 141.9–169.0 |
| TSC 7 | 21.7 | 18.50–25.49 | 37.3 | 31.31–44.38 |
| TSC 8 | 69.5 | 60.05–80.48 | 103.2 | 87.83–121.3 |
| TSC 9 | 25.2 | 19.39–32.75 | 115.3 | 99.15–134.1 |
| TSC 10 | 77.8 | 74.16–81.57 | 93.2 | 83.85–103.6 |
| TSC 11 | 44.0 | 38.48–50.43 | 44.8 | 40.04–50.22 |
| TSC 12 | 1160.3 4 | 219.7–6129 | 136.6 | 109.7–170.0 |
| Kojic acid | 114.1 | 105.9–123.0 | 152.7 | 138.4–168.6 |
| DMSO | 8019.8 | 140.5–457,651 | 166.4 | 153.4–180.6 |
1 Inhibitor concentration required for 50% inhibition; 2 confidence interval; 3 change in color of the solution during 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay affected the IC50 value; 4 yellow color of the solution affected the spectroscopic measurement at 405 nm. DMSO, dimethyl sulfoxide.