Table 2.
Patient Demographics and Main Characteristics of Case Reports
| Study | Study design | Study population | COVID-19 | Sex | Mean age, y | Ongoing therapy | Symptoms | Diagnosis | Treatment | Hospitalization | ICU | Mechanical ventilation | Death | Risk factors |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mazza et al16 | Case report | 1 severe UC | 1 | F | 80 | Mesalamine | Fever, diarrhea, anemia, dry cough, pneumonia | NPS, CT scan | Noninvasive ventilation Lopinavir/ritonavir Hydroxychloroquine Steroid |
1 | 0 | 0 | 1 | / |
| Jacobs et al18 | Case report | 1 UC | 1 | F | 33 | TOFA | Fever, chills, cough, myalgias, sore throat, fatigue, night sweats | NPS | TOFA | 0 | 0 | 0 | 0 | / |
| Kunisaki et al19 | Case report | 1 UC | 1 | M | 60 | IFX + azathioprine Mesalamine |
Cough and fever | NPS, CT scan | - | 1 | 0 | 0 | 0 | / |
| Tursi et al22 | Case report | 1 CD | 1 | M | 30 | Mesalamine Adalimumab |
Fever Chest pain |
NPS, CT scan | Noninvasive ventilation | 1 | 0 | 0 | 0 | / |
| Rosen et al27 | Case report | 1 severe UC during pregnancy | 1 | F | 26 | None | Abdominal pain, diarrhea, hematochezia, urgency | NPS | Steroid Antibiotic Hydroxychloroquine Cyclosporine |
1 | 0 | 0 | 0 | / |
| Dolinger et al29 | Case report | 1 pediatric CD | 1 | M | 14 | / | Fever, abdominal pain, erythematous maculopapular facial rash | / | Hydroxychloroquine Antibiotic Infliximab |
1 | 0 | 0 | 0 | / |
| Wolf et al38 | Case report | 1 CD | CD | M | 85 | None | Diarrhea, anorexia, fatigue, cough, weight loss | NPS | Bismuth subsalicylate | 0 | 0 | 0 | 0 | / |
| Di Ruscio et al32 | Case report | 1 severe UC | UC | F | 60 | Infliximab | Fever, cough, dyspnea, diarrhea, abdominal pain, fatigue | NPS, chest radiography, CT scan | Hydroxychloroquine, darunavir/cobicistat, supplemental oxygen | 1 | 0 | 0 | 0 | / |
| Bezzio and Saibeni34 | Case report | 1 severe UC | UC | M | 40 | Oral steroid | Diarrhea, abdominal pain, fever, cough | NPS, chest radiography | Azithromycin, hydroxychloroquine | 1 | 0 | 0 | 0 | / |
| Bezzio et al33 | Case report | 1 severe UC | UC | M | 36 | Mesalamine | Diarrhea, fever, dyspnea, cough | NPS, CT scan | Infliximab | 1 | 0 | 0 | 0 | / |
| Calabrese et al35 | Case report | 1 UC | UC | F | 19 | None | Fever, nausea, vomiting, diarrhea, anosmia, ageusia | NPS, CT scan | Hydroxychloroquine | 1 | 0 | 0 | 0 | / |
| Giulia and Patrizia36 | Case report | 1 severe pediatric CD | CD | F | 17 | Adalimumab | Fever, fatigue, dyspnea | NPS | None | 1 | 0 | 0 | 0 | / |
CD, Crohn’s disease; COVID-19, coronavirus disease 2019; F, female; IBD, inflammatory bowel disease; ICU, intensive care unit; IFX, infliximab; M, male; NPS, nasopharyngeal swab; TOFA, tofacitinib; UC, ulcerative colitis; -, not applicable; /, not reported.