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| Dosing |
Initial dose of 400 mg (flat dose) [63] or 4–8 mg/kg (rheum) infused over more than 60 min
If initial dose not effective, may administer second dose (in same dosage as initial dose) after 12 h
No more than 2 doses should be given; maximum single dose is 800 mg
|
| Adverse effects | Increased risk of infection, injection site reactions, elevated liver enzymes, risk of GI perforation |
