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. 2021 Jan 11;11:615378. doi: 10.3389/fgene.2020.615378

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Copyright © 2021 Stewart, Sage, Enfield, Marshall, Cohn and Lam.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of HMGA1 and HMGA1-lnc is associated with tumor stage. Expression of HMGA1-lnc decreases with increasing tumor stage (A), whereas HMGA1 expression increases with higher grade tumors (B). Tumors with high levels of HMGA1-lnc expression (Tertiles) had significantly higher levels of HMGA1 methylation than tumors with low levels of HMGA1-lnc (C). Expression of HMGA1 is higher in tumors with low levels of HMGA1 DNA methylation compared to tumors with high levels of DNA methylation (tertiles n = 30) (D).