Table 3.
List of Immunogenic and Antigenic Epitopes for MHC-I, MHC-II restricted T-cell and B-cell Epitopes.
Protein | Coded | Type | MHC-I restricted T-cell |
MHC-II restricted T-cell |
B-cell |
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sequence | Proteins | Epitope | Alleles | Scaled Score of |
Epitope | Alleles | Scaled Score of |
Epitope | Scaled Score of |
||||
Immunogenicity | Antigenicity | Immunogenicity | Antigenicity | Immunogenicity | Antigenicity | ||||||||
TENLLLYIDINGNLHPDSATLVSDIDITFLKKDAPYIVGDVVQEGVLTAVVIPTKKAGGTTEMLAKA | NSP3 | Immunogenic | FLKKDAPYI | HLA-A*31:01 | 0.8640 | 0.3890 | ITFLKKDAPYIVGDV | HLA-DRB3*01:01 | 0.9804 | 0.3036 | TLVSDIDITFLKKDAP | 0.8810 | 0.7314 |
KGSFLNGSCGSVGFNIDYDCVSFCY | 3CL-Proteinase | Immunogenic | FLNGSCGSV | HLA-A*02:03 | 0.6552 | 0.3342 | CGSVGFNIDYDCVSF | HLA-DQA1*01:01/DQB1*05:01 | 0.9114 | 0.7499 | CGSVGFNIDYDCVSFC | 0.7143 | 0.7401 |
Antigenic | |||||||||||||
FCDLKGKYVQIPTTCANDPVGFTLKNTVCTVCG | NSP10 | Immunogenic | DLKGKYVQI | HLA-B*08:01 | 0.9136 | 0.7542 | KGKYVQIPTTCANDP | HLA-DRB1*04:01 | 0.9818 | 0.1892 | TTCANDPVGFTLKNTV | 0.9048 | 0.6813 |
TLQQIELKFNPPALQDAYY | NSP3 | Immunogenic | NPPALQDAY | HLA-B*35:01 | 0.8106 | 0.4557 | QIELKFNPPALQDAY | HLA-DRB3*02:02 | 0.9485 | 0.6409 | LQQIELKFNPPALQDA | 0.3333 | 0.8433 |
FLPGVYSVIYLYLTFYLTNDVSFLAHIQWMV | NSP4 | Immunogenic | VSFLAHIQW | HLA-B*57:01 | 0.9980 | 0.7866 | GVYSVIYLYLTFYLT | HLA-DPA1*01:03/DPB1*02:01 | 0.9933 | 0.3326 | YSVIYLYLTFYLTNDV | 0.9762 | 0.4726 |
Antigenic |