Fig. 2.

Expansion of A3 paralogs. (A) Amino acid motifs within the zinc deaminase domain of the three A3 paralogs. Differences highlighted in grey and underlined. (B) Expansion of paralogs in different branches of placental mammals. A3Z1 has been independently lost in several taxonomic classes. Branch length is not drawn to timescale. Table lists number of paralogs and not number of gene products. Taxonomic relationships designed in consultation with the Tree of Life web project. (C) Diagram of the A3 gene locus in humans and primates. Adjacent paralogs (e.g. A3Z2a-A3Z1b) represent fused paralogs in a single gene product.