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. 2021 Jan 11;11:616947. doi: 10.3389/fgene.2020.616947

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Copyright © 2021 Wang, Zhao, Zhang, Zhu, Su, Qi, Deng and Xiao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nrf1 overexpression alleviated TEC pyroptosis in OGD/R-stimulated TCMK-1 cells. (A) Representative photomicrographs of Nrf1 expression in TCMK-1 cells by immunofluorescence, 400×, scale bar = 20 μm. (B,C) Western blot analysis of Nrf1, GSDMD-N, NLRP3, and caspase-1 expression in TCMK-1 cells. (D) Cell viability was detected by CCK-8 assay. (E) The LDH release was detected by activity assays. (F) IL-1β and IL-18 contents were measured by using ELISA kits. Data are expressed as the mean ± SD. n = 3 per group. *P < 0.05 vs. TCMK-1/wt con group, ∧P > 0.05 vs. TCMK-1/wt con group, #P < 0.05 vs. OGD/R-induced TCMK-1/wt group, one-way ANOVA.