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. 2021 Jan 18;22(2):914. doi: 10.3390/ijms22020914

Figure 7.

Figure 7

Expression of GDAP1 or the GDAP-Leu239Phe allele suppresses the sensitivity of the csg2Δ mutant to Ca2+ ions even in the presence of myriocin. (a) Schematic representation of the sphingolipid biosynthesis pathway. The step inhibited by myriocin is indicated. (GDP) guanosine diphosphate. (b) The growth of wild-type and csg2Δ mutant strains transformed with empty vector ([-]), or vectors carrying the cDNA of GDAP1, ([GDAP1]) or GDAP1 variants ([GDAP1-Gly327Asp] and [GDAP1-Leu239Phe]) was compared on YPD media or YPD containing 0.4 M calcium chloride (+CaCl2) or 0.4 M CaCl2 and 1 µM myriocin (+CaCl2 + Myriocin).