Table 3.
Diagnostic accuracy for the assessment of GGO per patient.
| Sensitivity | Specificity | PPV | NPV | Accuracy | ||
|---|---|---|---|---|---|---|
| Overall | MPR | 95.6 % (855/894) [94.2−97.0%] |
86.1 % (186/216)[84.1−88.2%] | 96.6 % (855/885)[95.2−98.0%] | 82.7 % (186/225)[81.1−84.1%] | 93.8 % (1041/1110)[92.4−95.1%] |
| MinIP | 99.9 % (893/894) [98.5−100.0%] |
95.8 % (207/216)[94.1−97.5%] | 99.0 % (893/902)[98.1−99.8%] | 99.5 % (207/208)[99.2−99.9%] | 99.1 % (1100/1110)[98.3−99.8%] | |
| Reader 1 | MPR | 95.3 % (142/149) [93.1−97.4%] |
94.4 % (34/36)[92.3−96.6%] | 98.6 % (142/144)[97.7−99.7%] | 82.9 % (34/41)[80.2−84.9%] | 95.1 % (176/185)[93.2−97.4%] |
| MinIP | 100 % (149/149) [100.0 %] |
97.2 % (35/36)[95.2−99.3%] | 99.3 % (149/150)[98.4−99.9%] | 100 % (35/35)[100.0 %] | 99.4 % (184/185)[98.9−99.9%] | |
| Reader 2 | MPR | 95.3 % (142/149) [93.1−97.4%] |
88.9 % (32/36)[86.5−91.2%] | 97.3 % (142/146)[95.3−99.8%] | 82.1 % (32/39)[80.1−84.3%] | 94.0 % (174/185)[91.2−97.0%] |
| MinIPx | 100 % (149/149) [100.0 %] |
97.2 % (35/36)[95.2−99.3%] | 99.3 % (149/150)[98.4−99.9%] | 100 % (35/35)[100.0 %] | 99.4 % (184/185)[98.9−99.9%] | |
| Reader 3 | MPR | 95.3 % (142/149) [93.2−98.4%] |
77.8 % (28/36)[75.2−81.2%] | 94.7 % (142/150)[92.1−96.6%] | 80.0 % (28/35)[77.3−83.1%] | 91.9 % (170/185)[89.8−94.2%] |
| MinIP | 100 % (149/149) [100.0 %] |
97.2 % (35/36)[95.2−99.3%] | 99.3 % (149/150)[98.4−99.9%] | 100 % (35/35)[100.0 %] | 99.4 % (184/185)[98.9−99.9%] | |
| Reader 4 | MPR | 96.0 % (143/149) [93.5−98.6%] |
80.6 % (29/36)[77.2−83.7%] | 95.3 % (143/150)[93.1−97.6%] | 82.9 % (29/35)[79.3−86.1%] | 92.9 % (172/185)[90.2−95.2%] |
| MinIP | 100 % (149/149) [100.0 %] |
97.2 % (35/36)[95.2−99.3%] | 99.3 % (149/150)[98.4−99.9%] | 100 % (35/35)[100.0 %] | 99.4 % (184/185)[98.9−99.9%] | |
| Reader 5 | MPR | 95.3 % (142/149) [93.1−97.4%] |
77.8 % (28/36)[73.1−81.1%] | 94.7 % (142/150)[92.1−96.6%] | 80.0 % (28/39)[77.1−83.3%] | 91.9 % (170/185)[89.2−94.1%] |
| MinIP | 100 % (149/149) [100.0 %] |
97.2 % (35/36)[95.2−99.3%] | 99.3 % (149/150)[98.4−99.9%] | 100 % (35/35)[100.0 %] | 99.4 % (184/185)[98.9−99.9%] | |
| Reader 6 | MPR | 96.6 % (144/149) [94.3−98.7%] |
86.1 % (31/36)[84.2−88.3%] | 96.6 % (144/149)[94.3−98.9%] | 86.1 % (31/36)[84.2−88.3%] | 94.6 % (175/185)[91.7−97.5%] |
| MinIP | 99.3 % (148/149) [98.8−99.8%] |
88.9 % (32/36)[86.3−91.2%] | 97.4 % (148/152)[95.1−99.5%] | 97.0 % (32/33)[95.3−98.8%] | 97.2 % (180/185)[95.1−99.2%] |
Data in brackets are numerators and values in square brackets are 95 % confidence intervals. Reader 1 had 10 year of experience in chest imaging; reader 2, 9 years; reader 3, 6 years; reader 4, 6 years; reader 5, 5 years; and reader 6, 5 years.
GGO: ground-glass opacity; MinIP: minimum intensity projection; MPR: multiplanar reformat; PPV: positive predictive value; NPV: negative predictive value.