Table 4.
Diagnostic accuracy for the assessment of GGO per lung lobe.
| Sensitivity | Specificity | PPV | NPV | Accuracy | ||
|---|---|---|---|---|---|---|
| Overall | MPR | 91.9 % (3530/3840) [91.2−92.8%] |
94.9 % (1623/1710) [93.8−95.9%] | 97.6 % (2530/3617) [96.4−98.8%] | 84.0 % (1623/1933) [82.5−85.5%] | 92.8 % (5153/5550) [91.5−94.3%] |
| MinIP | 98.7 % (3791/3840) [97.5−99.7%] |
98.9 % (1691/1710) [97.9−99.9%] | 99.5 % (3791/3810) [99.2−100.0%] | 97.2 % (1691/1740) [96.3−98.3%] | 98.8 % (5482/5550) [97.8−99.8%] | |
| Reader 1 | MPR | 91.9 % (588/640) [90.2−93.3%] |
98.6 % (281/285)[97.5−99.8%] | 99.3 % (588/592)[98.8−99.9%] | 84.4 % (281/333)[82.2−86.4%] | 93.9 % (869/925)[92.5−95.2%] |
| MinIP | 99.1 % (634/640) [0.98.4−99.8%] |
99.3 % (283/285) [98.9−99.9%] | 99.7 % (634/636) [99.2.−100.0%] | 97.9 % (283/289) [96.2−99.4%] | 99.1 % (917/925) [98.4−99.9%] | |
| Reader 2 | MPR | 91.4 % (585/640) [89.3−93.5%] |
97.9 % (279/285)[95.6−99.3%] | 99.0 % (585/591)[98.1−99.9%] | 83.5 % (279/334)[81.4−85.5%] | 93.4 % (864/925)[91.5−95.3%] |
| MinIP | 98.7 % (632/640) [97.7−99.6%] |
99.3 % (283/285) [98.9−99.9%] | 99.7 % (632/634)[99.4−100.0%] | 97.3 % (283/291)[95.3−99.3%] | 98.9 % (915/925)[98.2−99.6%] | |
| Reader 3 | MPR | 91.9 % (588/640) [90.0−93.7%]] |
93.7 % (267/285)[92.4−95.1%] | 97.0 % (588/606)[95.9−98.1%] | 83.7 % (267/319) [81.7−85.6%] | 92.4 % (855/925)[91.2−94.1%] |
| MinIP | 98.6 % (631/640) [97.3−99.8%] |
98.9 % (282/285)[97.9−99.9%] | 99.5 % (631/634)[99.2−100.0%%] | 96.9 % (282/291)[95.4−98.2%] | 99.0 % (916/925)[98.0−99.8%] | |
| Reader 4 | MPR | 92.0 % (589/640) [90.1−93.9%] |
94.0 % (268/285)92.2−95.8%] | 97.2 % (589/606) [96.1−98.1%] | 84.0 % (268/285)[81.8−86.4%] | 92.6 % (857/925)[91.3−94.3%] |
| MinIP | 98.7 % (632/640) [97.7−99.6%] |
99.3 % (283/285)[98.9−99.9%] | 99.7 % (632/634)[99.4−100.0%] | 97.3 % (283/291)[95.3−99.3%] | 98.9 % (915/925)[98.2−99.6%] | |
| Reader 5 | MPR | 91.4 % (585/640) [89.5−93.3%] |
97.9 % (279/285) [96.8−98.9%] | 99.0 % (585/591) [98.0−99.9%] | 83.5 % (279/334) 81.5−85.4%] | 93.4 % (864/925) [92.3−94.5%] |
| MinIP | 98.6 % (631/640) [97.3−99.8%] |
98.9 % (282/285)[97.9−99.9%] | 99.5 % (631/634)[99.2−100.0%%] | 96.9 % (282/291)[95.4−98.2%] | 99.0 % (916/925)[98.0−99.8%] | |
| Reader 6 | MPR | 93.0 % (595/640) [92.0−94.2%] |
87.4 % (249/285) [85.3−89.5%] | 94.3 % (595/631) [93.1−95.5%] | 84.7 % (249/294) [82.6−86.7%] | 91.2 % (844/925)[90.2−92.1%] |
| MinIP | 98.6 % (631/640) [97.76−99.5%] |
97.5 % (278/285)[95.4−99.1%] | 98.9 % (631/638)[98.0−99.8%) | 96.9 % (278/287)[95.0−99.0%] | 98.2 % (909/925)[97.3−99.2%] |
Data in brackets are numerators and values in square brackets are 95 % confidence intervals. Reader 1 had 10 year of experience in chest imaging; reader 2, 9 years; reader 3, 6 years; reader 4, 6 years; reader 5, 5 years; and reader 6, 5 years.
GGO: ground-glass opacity; MinIP: minimum intensity projection; MPR: multiplanar reformat; PPV: positive predictive value; NPV: negative predictive value.