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. 2021 Jan 17;10(1):66–80. doi: 10.1080/22221751.2020.1865840

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Structural comparison of PLPs among four CoVs. (A) Detailed structure of PDCoV PLpro from δ-CoV (blue). (B) Structure of SARS-CoV PLpro from β-CoV (PDB ID: 2FE8, salmon[27]). (C) Structure of MERS-CoV PLpro from β-CoV (PDB ID: 4RNA, magenta [60]). (D) Structure of IBV PLpro from γ-CoV (PDB ID: 4X2Z, cyan [24]). From A to D, the secondary structures (helices, strands, and loops) are marked; Zn²⁺ ions are shown as spheres. Regions that show significant differences among genera are indicated by arrows.