Skip to main content
. 2021 Jan 17;10(1):66–80. doi: 10.1080/22221751.2020.1865840

Figure 4.

Figure 4.

Structural comparison of Ubl2 from three CoV genera. (A) Detailed structure of PDCoV Ubl2 from δ-CoV (yellow). (B) Structure of SARS-CoV PLpro from β-CoV (PDB ID: 2fe8, salmon). (C) Structure of IBV PLpro from γ-CoV (PDB ID: 4×2z, cyan). From A to C, secondary structures (helices, strands and loops) are marked. (D) and (E) Crystal structures of SARS-CoV Ubl2-PLpro (PDB ID: 2fe8, salmon) and MHV DPUP-Ubl2-PLP2 (PDB ID: 4ypt, warm pink) are superimposed over the structure of PDCoV Macro-Ubl2-PLpro (in multiple colours). Macro of PDCoV, the DPUP (domain preceding Ubl2 and PLP2) of MHV and the PLPs from PDCoV and SARS-CoV are shown as ribbons, and MHV, Ubl2 from PDCoV, SARS-CoV and MHV are shown as cartoons. The deviation angles of Ubl2 are within the black lines.