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. 2021 Jan 11;11:608518. doi: 10.3389/fphar.2020.608518

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Copyright © 2021 Wu, Kong, Lou, Li, Yang, Xu, Cui, Hao and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FMNT enhanced wound healing in a dermal wound model in mice. (A) A dermal wound model in mice was established to investigate the effects of FMNT on wound healing. (B) The wounds were photographed at postoperative days 2, 4, 6, 8, and 10. Wound area reduction was calculated as the percentage of the initial wound area. (C) Average body weight was recorded for the mice. (D) Organ indexes were calculated for mouse hearts, livers, spleens, kidneys and lungs. (E) The effects of FMNT on Erk1/2 and Akt phosphorylation in mice were evaluated with Western blot analysis. The data were presented as mean ± SD (n = 5 or 6). ^* p < 0.05, **p < 0.01, and ***p < 0.001 compared with the control group. ^# p < 0.05, ^## p < 0.01, and ^### p < 0.001 compared with the FMNT (50 μM) group.