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. 2021 Jan 11;11:608518. doi: 10.3389/fphar.2020.608518

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Copyright © 2021 Wu, Kong, Lou, Li, Yang, Xu, Cui, Hao and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of FMNT on the growth and proliferation of HUVECs. (A) Chemical structure of FMNT. (B) Cytotoxic effect of FMNT (2.5–100 μM, 24 h) on HUVECs was evaluated by using a CCK8 assay. (C) Effects of FMNT (10, 20, and 40 μM, 24 h) on the proliferation HUVECs was evaluated using an EdU kit. The EdU-positive cells in each group were quantified as the percentage of the cells in control group. (D) Effects of FMNT (60, 80, and 100 μM, 24 h) on the apoptosis of HUVECs was assessed using an Annexin V-FITC/PI dual staining detection kit. VEGF (40 ng/ml) was used as a positive control for endothelial growth and proliferation. The data were presented as mean ± SD (n = 3). ^* p < 0.05, **p < 0.01, and ***p < 0.001 compared with the control group.