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. 2021 Jan 11;11:607797. doi: 10.3389/fphar.2020.607797

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Copyright © 2021 Singh, Sharma, Kumari, Sharma and Purohit

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of hesperidin on the latency to PTZ-induced seizures (Stage 3). veh/naïve group was not exposed to PTZ, hence not shown in the figure. ^a P < 0.05 as compared to veh/ptz (vehicle control) group; ^b P < 0.05 as compared to hes1/ptz group and; ^c P < 0.05 as compared to hes5/ptz group. The results expressed as mean ± SEM. veh/ptz: system water incubated group exposed to PTZ; hes1/ptz: Hesperidin 1 μM incubated group exposed to PTZ; hes5/ptz: Hesperidin 5 μM incubated group exposed to PTZ and; hes10/ptz: Hesperidin 10 μM incubated group exposed to PTZ.