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. 2021 Jan 11;11:586653. doi: 10.3389/fphar.2020.586653

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Copyright © 2021 Zhu, Chen, Lin, Tang, Min and Zheng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LINC-PINT suppressed EMT, tumor proliferation, and invasion by blocking Wnt/β-catenin signaling pathway in GBM. (A) Western blot assay for EMT markers N-cadherin and Vimentin and Wnt/β-catenin markers β-catenin, CD44, and TCF1/TCF7 detected in transfected U87 and LN229 cells with or without Wnt/β-catenin pathway activator LiCL (20 mmol/L, treated for 24 h). (B) Relevant expression level of LINC-PINT in transfected U87 and LN229 cells treated with or without LiCL was determined by qRT-PCR assay. (C) The cell viability of transfected U87 and LN229 cells treated with or without LiCL was detected by CCK8 assay. (D) The cell invasion ability of transfected U87 and LN229 cells treated with or without LiCL was detected by transwell assay. n.s., no significance. **p < 0.01, ***p < 0.001, ****p < 0.0001.