Table 1.
Personal and laboratory findings of 57 cases of COVID-19 with pneumonia in the general, severe, and critical groups.
| Variable | Disease subtype |
|||
|---|---|---|---|---|
| General (n = 20) | Severe (n = 19) | Critical (n = 18) | P value | |
| Age (year), median (IQR) | 59 (53–63) | 66 (61–74) | 68 (55–70) | 0.026* |
| Sex (male), (proportion) | 8 (40.0%) | 9 (47.4%) | 12 (66.7%) | 0.242 |
| Length of stay in hospital (d), median (IQR) | 20 (14–24) | 23(19–27) | 22(13–28) | 0.221 |
| Underlying disease, (proportion) | 10 (50.0%) | 12 (63.2%) | 14 (77.8%) | 0.208 |
| Hypertension, (proportion) | 7 (35.0%) | 8 (42.1%) | 12 (66.7%) | 0.02* |
| Diabetes mellitus, (proportion) | 3 (15.0%) | 0 (0%) | 6 (33.3%) | 0.021* |
| WBC (×109 L−1), median (IQR) | 4.96 (4.60–6.60) | 6.40 (4.90–9.00) | 8.00 (6.60–11.60) | 0.002** |
| Neutrophil ratio (%), median (IQR) | 56.2 (60.0–66.7) | 66.5 (59.7–74.0) | 88.7 (75.4–91.5) | < 0.0001*** |
| Lymphocyte ratio (%), median (IQR) | 30.95 (21.50–36.10) | 20.50 (13.70–28.50) | 6.30 (3.20–13.90) | < 0.0001*** |
| Monocyte ratio (%), median (IQR) | 9.4 (6.7–11.8) | 9.0 (7.9–10.5) | 3.7 (2.5–6.6) | 0.001** |
| Platelet count (×109 L−1), median (IQR) | 198.5 (141.0–269.5) | 260.0 (213.0–322.0) | 145.0 (98.3–288.0) | 0.08 |
| CRP (mg·L−1), median (IQR) | 5.0 (5.0–10.9) | 6.0 (4.0–25.7) | 47.1 (23.1–100.1) | 0.001** |
| PCT (ng·mL−1), median (IQR) | 0.033 (0.027–0.054) | 0.057 (0.033–0.076) | 0.147 (0.099–0.336) | < 0.0001*** |
| D-dimer (mg·L−1), median (IQR) | 0.87 (0.50–1.30) | 1.60 (0.60–3.20) | 5.10 (3.10–19.50) | < 0.0001*** |
| IL-6 (pg·mL−1), median (IQR) | 2.47 (1.50–3.70) | 5.00 (1.60–17.10) | 12.40 (6.50–55.20) | 0.002** |
| ALT (U·L−1), median (IQR) | 23.0 (17.3–51.8) | 35.0 (32.0–73.0) | 28.0 (17.5–40.8) | 0.149 |
| AST (U·L−1), median (IQR) | 20.5 (17.0–25.0) | 34.0 (21.0–40.0) | 30.5 (19.3–48.0) | 0.05 |
| ALB (g·L−1), median (IQR) | 36.5 (32.5–41.2) | 36.7 (33.9–40.7) | 31.9 (28.7–34.7) | 0.001** |
| Creatinine (μmol·L−1), median (IQR) | 59.5 (50.8–67.8) | 52.0 (42.0–64.0) | 56.0 (41.0–66.3) | 0.362 |
| CK (U·L−1), median (IQR) | 39.0 (24.0–58.0) | 26.0 (17.0–42.0) | 39.5 (22.8–56.5) | 0.204 |
| LDH (U·L−1), median (IQR) | 204.0 (177.8–250.5) | 219.0 (183.0–253.0) | 377.0 (350.0–592.8) | < 0.0001*** |
| Myoglobin (μg·L−1), median (IQR) | 28.4 (19.0–41.8) | 28.5 (21.2–34.8) | 60.0 (30.8–139.0) | 0.006** |
Significant differences among general, severe, and critical groups are indicated by asterisks (*: P < 0.05; **: P < 0.01; ***: P < 0.001).
IQR: interquartile range; WBC: white blood cell; CRP: C-reactive protein; PCT: procalcitonin; ALT: alanine aminotransferase; AST: aspartate aminotransferase; ALB: albumin; CK: creatine kinase; LDH: lactate dehydrogenase.