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. 2021 Jan 11;7:603701. doi: 10.3389/fmolb.2020.603701

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Copyright © 2021 Ling, Ye, Zhao, Jiang, Liang and Tang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Biological behavior of CD200R1 in lung adenocarcinoma. (A) Baseline expression of CD200R1 in four kinds of cancer cells; (B) Two shRNA targeting CD200R1 was transfected into A549, effect of knock down was confirmed by western blot; (C) Cancer cell growth rate was increased after CD200R1 was knocked down; (D) S phase distribution was increased after CD200R1 was down-regulated. (E) Percentage of Ki67 positive was used to confirm the effect of CD200R1 on cell proliferation. (F) Apoptosis rate was studied by ANNEXINV stain; (G,H) The effect of CD200R1 on cell migration was studied by transwell and wound healing assay; (I) The expression of Snail and Vimentin was increased and that of E-cadherin was reduced, indicted EMT was occur after CD200R1 was knocked down.