Table 2.

GRADE assessment of quality of evidence.

The Efficacy and Safety of Laser Interstitial Thermal Therapy on Patients Suffering from Supratentorial Newly Diagnosed Glioblastoma
Patient or population: patient older than 18 years suffering from supratentorial newly diagnosed glioblastoma. Intervention: stereotactic laser ablation.
Primary outcomes	The point estimate	No. of participants (studies)	Quality of the evidence (GRADE)
Overall survival	The point estimate is 10.2 months. The medians ranged from 3.3 to 32 months.	111 (10 non-RCT)	Very low a,b,c
Progression free survival	The point estimate is 7 months. The medians ranged from 2 to 31.9 months.	106 (9 non-RCT)	Very low a,b,c
Complications	The point estimate is 33.7%.	111 (11 non-RCT)	Very low a,b,c
GRADE Working Group grades of evidence (GradePro). High quality: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate quality: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low quality: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low quality: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect.

^a Risk of bias: no blinding of therapists and participants (not possible), and no randomization. ^b Imprecision: small number of participants and broad CI. ^c Selection bias: retrospective patient selection.