Table 1.

Differential expression of TTP-bound mRNAs during different phases of inflammation.

Inflammatory Onset 1		Peak Inflammation 2		Early Resolution 3
Gene ID	log2FC (TTP-wt vs. TTP-AA)	Gene ID	Δ log2FC (TTP-ko/ctr vs. TTP-wt/ctr)	Gene ID	Δ log2FC (TTP-ko/ctr vs. TTP-wt/ctr)
Ier3	0.91	Gdf15	1.73	Cxcl1	3.86
Plau	0.57	Eno2	1.26	Cxcl2	3.34
Lpl	0.56	Mllt11	1.23	Eno2	2.07
Mdm2	0.46	Cxcl1	1.00	Mllt11	1.73
Mat2a	0.44	Cxcl2	0.94	Ccl3	1.46
Plek	0.36	Rusc2	0.67	Il10	1.39
Canx	0.35	Ier3	0.45	Tnf	1.36
Actr2	0.26	Zeb2	0.26	Rusc2	0.87
		Il10	0.25	Il27	0.74
		Prdx1	0.20	Notch1	0.50
		Notch1	0.14	Maf	0.35
		Sfmbt1	0.13	Ccl4	0.35
		Cish	0.03	Fam49b	0.33
		Cflar	0.02	Cdkn1a	0.28
				Zeb2	0.28
				Ier3	0.23
				Il10ra	0.21
				Dusp1	0.05
				Ccl2	0.05
				Aff1	0.02

Green: feedback regulators; red: inflammatory TTP targets; blue: anti-inflammatory TTP targets. ¹ Top 50 3′UTR-bound TTP targets, filtered for targets with higher induction of mRNA expression in TTP-wt as compared to inactive TTP-AA expressing BMDM after 1 h LPS (from [37]). ² Top 50 3′UTR-bound TTP targets, filtered for targets with higher induction of mRNA expression in TTP-k/o as compared to TTP-wt BMDM after 3 h LPS (from [74]). ³ Top 50 3′UTR-bound TTP targets, filtered for targets with higher induction of mRNA expression in TTP-k/o as compared to TTP-wt BMDM after 6 h LPS (from [74]).