Table 1.
Inflammatory Onset 1 | Peak Inflammation 2 | Early Resolution 3 | |||
---|---|---|---|---|---|
Gene ID | log2FC (TTP-wt vs. TTP-AA) |
Gene ID | Δ log2FC (TTP-ko/ctr vs. TTP-wt/ctr) |
Gene ID | Δ log2FC (TTP-ko/ctr vs. TTP-wt/ctr) |
Ier3 | 0.91 | Gdf15 | 1.73 | Cxcl1 | 3.86 |
Plau | 0.57 | Eno2 | 1.26 | Cxcl2 | 3.34 |
Lpl | 0.56 | Mllt11 | 1.23 | Eno2 | 2.07 |
Mdm2 | 0.46 | Cxcl1 | 1.00 | Mllt11 | 1.73 |
Mat2a | 0.44 | Cxcl2 | 0.94 | Ccl3 | 1.46 |
Plek | 0.36 | Rusc2 | 0.67 | Il10 | 1.39 |
Canx | 0.35 | Ier3 | 0.45 | Tnf | 1.36 |
Actr2 | 0.26 | Zeb2 | 0.26 | Rusc2 | 0.87 |
Il10 | 0.25 | Il27 | 0.74 | ||
Prdx1 | 0.20 | Notch1 | 0.50 | ||
Notch1 | 0.14 | Maf | 0.35 | ||
Sfmbt1 | 0.13 | Ccl4 | 0.35 | ||
Cish | 0.03 | Fam49b | 0.33 | ||
Cflar | 0.02 | Cdkn1a | 0.28 | ||
Zeb2 | 0.28 | ||||
Ier3 | 0.23 | ||||
Il10ra | 0.21 | ||||
Dusp1 | 0.05 | ||||
Ccl2 | 0.05 | ||||
Aff1 | 0.02 |
Green: feedback regulators; red: inflammatory TTP targets; blue: anti-inflammatory TTP targets. 1 Top 50 3′UTR-bound TTP targets, filtered for targets with higher induction of mRNA expression in TTP-wt as compared to inactive TTP-AA expressing BMDM after 1 h LPS (from [37]). 2 Top 50 3′UTR-bound TTP targets, filtered for targets with higher induction of mRNA expression in TTP-k/o as compared to TTP-wt BMDM after 3 h LPS (from [74]). 3 Top 50 3′UTR-bound TTP targets, filtered for targets with higher induction of mRNA expression in TTP-k/o as compared to TTP-wt BMDM after 6 h LPS (from [74]).