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. 2021 Jan 19;7(1):65. doi: 10.3390/jof7010065

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Working model for GlcNAc import and its signaling in C. albicans. Exogenous GlcNAc is imported into cytosol through GlcNAc specific transporter, Ngt1. In the nucleus GlcNAc binds to GlcNAc sensor, Ngs1 to activate transcription of genes involved in various processes (37) as shown in the figure. Transcription factors, such as Rep1, which bind to DNA, recruit GlcNAc sensor Ngs1 at cognate gene promoters and transduce GlcNAc signaling. Ngs1 acts as a master regulator of GlcNAc signaling by regulating various cellular processes, such as GlcNAc transport (NGT1), GlcNAc metabolism (HXK1, NAG1, DAC1 etc.), GlcNAc scavenging (HEX1), morphogenesis (HWP1, ECE1 etc.), and other uncharacterized functions.